Exercise Metabolism, Second Edition, provides a systematic, in-depth examination of the regulation of metabolic processes during exercise. Exercise physiologists, exercise biochemists, and biochemists will find this book a comprehensive reference, using the up-to-date information and the nearly 1,000 references in their own research and writing. In addition, graduate students in these disciplines can learn firsthand about the various regulations of metabolic processes during exercise as they prepare for careers in exercise physiology or biochemistry.
Written by internationally recognized researchers, Exercise Metabolism, Second Edition, is both revised and expanded while retaining the essential elements of the first edition. It delves into the mobilization and utilization of substrates—glucose, lipid, and protein—during physical activity, and it explores metabolic factors in fatigue and metabolic adaptations to endurance training.
Chapter 1 provides an overview of exercise metabolism. Metabolism during high-intensity exercise and the transition from rest to exercise are covered in chapter 2, which details the so-called anaerobic energy pathways. Chapter 3 discusses the effects of exercise on carbohydrate metabolism in skeletal muscle, while chapter 4 provides an overview of the important metabolic functions of the liver during exercise.
Chapter 5 is a new chapter that addresses lactate transport in skeletal muscle, given the increased understanding of this topic since the first edition was published. Chapters 6 and 7 summarize the effects of exercise on lipolysis in adipose tissue and lipid metabolism in skeletal muscle, respectively. The contribution of protein and amino acids to exercise metabolism is discussed in chapter 8. Finally, metabolic factors in fatigue and the metabolic adaptations to endurance training are reviewed in chapters 9 and 10, respectively. Chapter-ending summaries help to condense the information and facilitate understanding.
Exercise Metabolism, Second Edition, is a valuable reference to exercise physiologists, exercise biochemists, and biochemists, and it serves as an ideal text for graduate students in these disciplines.
Chapter 1. Overview of Exercise Metabolism Lawrence L. Spriet, PhD, and Mark Hargreaves, PhD
Metabolic Fuels and Rates of ATP Production
Control of Metabolic Pathways
Signals Matching ATP Synthesis and ATP Demand
Chapter 2. Anaerobic Metabolism During Exercise Lawrence L. Spriet, PhD
Skeletal Muscle ATP Concentration Is Defended During Exercise
Importance of Anaerobic Metabolism
Sources of Anaerobic ATP
Regulation of Anaerobic Energy Provision
Intermittent High-Intensity Exercise
Anaerobic Metabolism at the Onset of Exercise
Chapter 3. Skeletal Muscle Carbohydrate Metabolism During Exercise Mark Hargreaves, PhD
Muscle Glycogenolysis and Glucose Uptake During Exercise
Regulation of Muscle Glycogenolysis
Regulation of Muscle Glucose Uptake
Regulation of CHO Oxidation
Postexercise CHO Metabolism
Chapter 4. Hepatic Metabolism During Exercise Michael Kjær, MD
Hepatic Glucose Output During Exercise: Glycogenolysis and Gluconeogenesis
Feedback Regulation of Hepatic Glucose Output
Feed-Forward Regulation of Hepatic Glucose Output
Regulatory Hormonal and Neural Mechanisms in Hepatic Glucose Production
Hepatic Uptake of Gluconeogenic Precursors
Chapter 5. Skeletal Muscle Lactate Transport and Transporters Arend Bonen, PhD
Lactate Transport System
Lactate Transport Proteins
MCT1 and MCT4 in Human Skeletal Muscle
Subcellular Distribution of MCT1 and MCT4 in Muscle
MCT1 and MCT4 Transporters and Lactate Transport
Effects of Training on MCT1 and MCT4
Possible Roles of MCTs
Chapter 6. Adipose Tissue Lipid Mobilization During Exercise Jeffrey F. Horowitz, PhD
Regulation of Lipolysis in Adipose Tissue
Measuring Lipolysis in Vivo
Regulation of Adipose Tissue Blood Flow
Other Triglyceride Sources
Lipolytic Response During Endurance Exercise
Endurance Exercise Training
Chapter 7. Skeletal Muscle Lipid Metabolism During Exercise Lorraine P. Turcotte, PhD
Plasma Long-Chain Fatty Acid Metabolism
Muscle Triacylglycerol Metabolism
Plasma Triacylglycerol Metabolism
Chapter 8. Effect of Exercise on Skeletal Muscle Protein and Amino Acid Metabolism in Humans Martin J. Gibala, PhD
Protein Turnover and Exercise
Skeletal Muscle Amino Acid Metabolism During Exercise
Influence of Protein or Amino Acid Ingestion on Muscle Adaptation During Recovery
Chapter 9. Metabolic Factors in Fatigue Kent Sahlin, PhD
Limits of Energetic Processes
Integrated View of Fatigue During Static and Dynamic Exercise
Chapter 10. Endurance Training-Induced Adaptations in Substrate Turnover and Oxidation Stuart M. Phillips, PhD
Study Design Considerations
Effect of Training on Substrate Turnover and Oxidation
Underlying Mechanisms of Training-Induced Adaptations
A reference for exercise physiologists, exercise biochemists, and biochemists. Also a text for graduate students in these areas of study.
Mark Hargreaves, PhD, returns as editor of this edition of the book. He has more than 20 years of research experience in exercise physiology and metabolism and has published numerous papers on exercise metabolism. He is a physiology professor at the University of Melbourne in Australia, where he earned his PhD in physiology in 1989. His master's degree, in exercise physiology, is from Ball State University in Muncie, Indiana.
Dr. Hargreaves was honored by the American College of Sports Medicine with a 1994 New Investigator Award. Also in 1994, he was awarded the McIntyre Prize by the Australian Physiological and Pharmacological Society.
Lawrence Spriet, PhD, is a professor in the human biology and nutritional sciences department at the University of Guelph. For 19 years he has been a researcher in the area of whole-body and skeletal muscle metabolism; he has received funding from the Natural Sciences and Engineering Research Council of Canada and the Canadian Institutes of Health Research. Dr. Spriet is a member of the American and Canadian Physiological Societies, American College of Sports Medicine, and the Canadian Society for Exercise Physiology. He has been an editorial board member or associate editor of numerous research journals in the field. He earned his doctorate degree at McMaster University in Hamilton, Ontario.
“This is a timely and thoughtful monograph which will be lucid and enlightening for the student and scientist of exercise metabolism.” John Sutton, MD, DSc, FRACP, FRCPC, FACSM, FACSP Professor, University of Sydney (review of first edition)
“This is a much needed book which provides a comprehensive and authoritative review of the biochemistry of exercise. The authors are all recognized leaders in exercise science, and the quality of the chapters is uniformly high. Researchers looking for an up-to-the-minute review, as well as students taking advanced classes in the physiology and biochemistry of exercise will find this an invaluable guide. It will certainly be one of the first books that I turn to when looking for authoritative comment on exercise metabolism. There is no other book currently available that gives a detailed account of the metabolic response to physical exercise.” Ron Maughan, PhD Professor, University of Aberdeen (review of first edition)
“Well-written overviews covering a dynamic field. There is a good balance between past and current research findings for the graduate student and researchers in the field of metabolism.” Bengt Saltin, MD Professor, The Copenhagen Muscle Research Centre (review of first edition)
“Exercise Metabolism provides a series of chapters that overview the field of exercise biochemistry. This rapidly growing field has amassed an overwhelming amount of new information; Exercise Metabolism provides an up-to-date summary of the most recent findings. As an investigator in the field of human exercise physiology, I feel this book is a valuable addition to my library. It brings together in one text the concepts and theories that define the role of energy exchange during exercise.” David Costill, PhD, FACSM Professor and Director, Human Performance Laboratory Ball State University (review of first edition)