The specific aim of this study was to explore effects of regular exercise on oxidative status of DNA in the aged animal model. Goto S, Radak Z: Regular exercise attenuates oxidative stress in aging rat tissues: A possible mechanism toward antiaging medicine. Radak Z, Chung HY, Goto S: Systemic adaptation to oxidative challenge induced by regular exercise.
Aging is associated with decline in physiological function in brain, skeletal muscle and other organs. Our purpose was to influence the brain function and alter age-associated decline with exercise and administration of IGF-1. Therefore we administered IGF-1 during a running exercise protocol to young and old Wistar rats. We have observed that exercise training without IGF-1 treatment improved brain function measured by the Morris maze test, and the age-associated decline was prevented by ...
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